P2 Malignant Epithelial Neoplasms PDF

Malignant Epithelial Neoplasms PDF Lecture

Powered By EmbedPress

Malignant Epithelial Neoplasms

Locally Invasive Malignant Neoplasms:

  • Definition: Malignant tumors that spread only locally with no distant metastatic potential.
  • Examples: Basal cell carcinoma, Osteoclastoma, Craniopharyngioma, Desmoid tumor.

Basal Cell Carcinoma (Rodent Ulcer):

  • Microscopic (MIC): Infiltration of subepithelial tissue with malignant basaloid cells showing peripheral palisading.
  • Grossly: Rounded ulcer with rolled inverted beaded edges, indurated base, and necrotic floor. Raised border is observed.

MALIGNANT TUMORS OF EPITHELIAL ORIGIN (CARCINOMAS)

  1. Carcinomas Arising from Surface Epithelium:
  1. Squamous Cell Carcinoma:
    • Grossly: Fungating, infiltrating, or ulcerating with raised everted edge, indurated base, and necrotic floor.
    • MIC: Subepithelial tissue infiltration by nests of malignant squamous epithelial cells with central keratin nests.
  2. Transitional Cell Carcinoma:
    • MIC: Complex papillary structures formed by malignant transitional epithelial cells.
    • Grossly: Papillary with infiltrating base.
  1. Carcinomas of Glandular Origin:
  1. Adenocarcinoma:
    • Characterized by variable-sized malignant acini.
  2. Mucin-Secreting Carcinomas:
    • Characterized by excessive mucin secretion by tumor cells.
  3. Carcinoma Simplex:
    • Malignant cells neither exhibit acinar pattern nor secrete mucin. Example: Breast carcinoma.

Examples:

  • Adenocarcinoma of the Colon:
    • MIC: Infiltrating malignant glands.
    • Gross Picture: Ulcerative Carcinoma.
  • Mucinous Adenocarcinoma of the Colon:
    • MIC: Mucinous adenocarcinoma with extracellular lakes of mucin.
  • Breast Carcinoma:
    • MIC: Small masses and cords of malignant cells separated by dense fibrous tissue stroma.
    • Grossly: Ill-defined mass, firm, and gritty consistency. Excessive fibrosis on the cut surface.
  • Carcinoma Lung
  • Hepatic Adenocarcinoma
  • Metastatic Adenocarcinoma in The Liver

Understanding the characteristics and microscopic appearance of malignant epithelial neoplasms is crucial for accurate diagnosis and appropriate treatment planning.

Rate this page